Risk stratification and early prevention of malignant ventricular arrhythmia: rationale and design

Background Malignant organic and hereditary ventricular arrhythmias lead to sudden death, accounting for a major death cause of Chinese individuals. Currently, the incidence and risk factors of ventricular arrhythmia remain unclear, and the therapeutics of malignant ventricular arrhythmia require further revising. Rationale The study of the incidence and risk factors of ventricular tachycardia with organic or heritable heart diseases in China will promote early intervention against sudden cardiac death. The improvement of catheter ablation, drug therapies and autonomic nerve intervention will provide patients with lower cost and more efficient diagnosis and treatment strategy. Design The study consists of four parts.①Risk stratification of ventricular tachycardia with organic or heritable heart diseases in China.②Evaluation and intervention strategies of autonomic nervous in ventricular tachycardia of organic heart disease.③Substrate intervention strategy for ventricular arrhythmia.④Demographics, risk stratification and intervention of hereditary malignant ventricular arrhythmia. Conclusion The study will construct the databases for ventricular arrhythmia and multidimensional risk stratification system, predicting the risk of the malignant ventricular arrhythmia and the reciprocal effective interventions. Key words: Ventricular arrhythmia; Risk factors; Catheter ablation; Pharmacological treatment; Autonomic nerve system