骨肉瘤
分化疗法
细胞分化
癌变
癌症研究
表型
癌症治疗
生物
医学
癌症
内科学
细胞培养
基因
遗传学
急性早幼粒细胞白血病
维甲酸
作者
Yingqian Chen,Ji Cao,Ning Zhang,Bo Yang,Qiaojun He,Xuejing Shao
标识
DOI:10.1016/j.drudis.2019.08.010
摘要
Differentiation therapy involves the use of agents that can induce differentiation in cancer cells, with the irreversible loss of tumour phenotype. The application of differentiation therapy in osteosarcoma has made progress because of a better understanding of the potential links between differentiation defects and tumorigenesis. Here, we review recent studies on differentiation therapy for osteosarcoma, describing a variety of differentiation inducers. By highlighting these examples of drug-induced osteosarcoma cell differentiation, we can acquire unique insights into not only osteosarcoma treatment, but also novel approaches to transform differentiating drugs into more effective therapies for other solid tumours.
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