化学
薗头偶联反应
乙酰化物
炔烃
镍
卤代芳基
还原消去
金属转移
催化作用
芳基
氧化加成
Stille反应
卤化物
光化学
钯
药物化学
有机化学
烷基
作者
Da Zhu,Ruijie Xu,Qi Wu,Haiyan Li,Jian-Ping Lang,Hong-Xi Li
标识
DOI:10.1021/acs.joc.0c01177
摘要
An efficient method for visible-light-initiated, nickel-catalyzed Sonogashira C(sp)-C(sp2) coupling has been developed via an energy-transfer mode. Thioxanthen-9-one as a photosensitizer could significantly accelerate the arylation of alkynes with a wide range of (hetero)aryl halides in high yields. The cross-coupling reaction undergoes the stepwise oxidative addition of an arylhalide to nickel(0), transmetalation of the resulting aryl-Ni(II) halide species with Zn(II) acetylide into aryl-Ni(II) acetylide species, energy transfer from the excited state of thioxanthen-9-one to aryl-Ni(II) acetylide, and reductive elimination to the aryl alkyne.
科研通智能强力驱动
Strongly Powered by AbleSci AI