生物
RNA剪接
选择性拼接
细胞生物学
祖细胞
SR蛋白
祖细胞
平衡
拼接因子
干细胞
RNA结合蛋白
遗传学
信使核糖核酸
基因
核糖核酸
作者
Tingsheng Yu,Oscar Cazares,Alison D. Tang,Hyun-Yi Kim,Tomas Wald,Adya Verma,Qi Liu,Mary Helen Barcellos-Hoff,Stephen N. Floor,Han-Sung Jung,Angela N. Brooks,Ophir D. Klein
标识
DOI:10.1016/j.devcel.2022.01.011
摘要
Alternative splicing generates distinct mRNA variants and is essential for development, homeostasis, and renewal. Proteins of the serine/arginine (SR)-rich splicing factor family are major splicing regulators that are broadly required for organ development as well as cell and organism viability. However, how these proteins support adult organ function remains largely unknown. Here, we used the continuously growing mouse incisor as a model to dissect the functions of the prototypical SR family protein SRSF1 during tissue homeostasis and renewal. We identified an SRSF1-governed alternative splicing network that is specifically required for dental proliferation and survival of progenitors but dispensable for the viability of differentiated cells. We also observed a similar progenitor-specific role of SRSF1 in the small intestinal epithelium, indicating a conserved function of SRSF1 across adult epithelial tissues. Thus, our findings define a regulatory mechanism by which SRSF1 specifically controls progenitor-specific alternative splicing events to support adult tissue homeostasis and renewal.
科研通智能强力驱动
Strongly Powered by AbleSci AI