生物过程
生化工程
稳健性(进化)
限制
原材料
合成生物学
工业生产
生物技术
计算机科学
生产(经济)
风险分析(工程)
工程类
生物
业务
计算生物学
经济
生态学
基因
宏观经济学
凯恩斯经济学
机械工程
生物化学
化学工程
作者
Marta Tous Mohedano,Oliver Konzock,Yun Chen
标识
DOI:10.1016/j.synbio.2021.12.009
摘要
The development of a cost-competitive bioprocess requires that the cell factory converts the feedstock into the product of interest at high rates and yields. However, microbial cell factories are exposed to a variety of different stresses during the fermentation process. These stresses can be derived from feedstocks, metabolism, or industrial production processes, limiting production capacity and diminishing competitiveness. Improving stress tolerance and robustness allows for more efficient production and ultimately makes a process more economically viable. This review summarises general trends and updates the most recent developments in technologies to improve the stress tolerance of microorganisms. We first look at evolutionary, systems biology and computational methods as examples of non-rational approaches. Then we review the (semi-)rational approaches of membrane and transcription factor engineering for improving tolerance phenotypes. We further discuss challenges and perspectives associated with these different approaches.
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