Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems Volume 12 Issue 1. January 2022 G. Ryan Crislip, G. Ryan Crislip Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorJermaine G. Johnston, Jermaine G. Johnston Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USASearch for more papers by this authorLauren G. Douma, Lauren G. Douma Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorHannah M. Costello, Hannah M. Costello Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAlexandria Juffre, Alexandria Juffre Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorKyla Boyd, Kyla Boyd Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorWendy Li, Wendy Li Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorCheoting C. Maugans, Cheoting C. Maugans Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorMiguel Gutierrez-Monreal, Miguel Gutierrez-Monreal Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorKaryn A. Esser, Karyn A. Esser Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Myology Institute, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAndrew J. Bryant, Andrew J. Bryant Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAndrew C. Liu, Andrew C. Liu Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Myology Institute, University of Florida, Gainesville, Florida, USASearch for more papers by this authorMichelle L. Gumz, Michelle L. Gumz Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida, USAMichelle.Gumz@medicine.ufl.eduSearch for more papers by this author G. Ryan Crislip, G. Ryan Crislip Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorJermaine G. Johnston, Jermaine G. Johnston Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USASearch for more papers by this authorLauren G. Douma, Lauren G. Douma Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorHannah M. Costello, Hannah M. Costello Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAlexandria Juffre, Alexandria Juffre Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorKyla Boyd, Kyla Boyd Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorWendy Li, Wendy Li Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorCheoting C. Maugans, Cheoting C. Maugans Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USASearch for more papers by this authorMiguel Gutierrez-Monreal, Miguel Gutierrez-Monreal Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USASearch for more papers by this authorKaryn A. Esser, Karyn A. Esser Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Myology Institute, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAndrew J. Bryant, Andrew J. Bryant Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, Florida, USASearch for more papers by this authorAndrew C. Liu, Andrew C. Liu Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Myology Institute, University of Florida, Gainesville, Florida, USASearch for more papers by this authorMichelle L. Gumz, Michelle L. Gumz Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida, USAMichelle.Gumz@medicine.ufl.eduSearch for more papers by this author Published online: 29 December 2021 https://doi.org/10.1002/cphy.c210011 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mechanisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskeletal, immune, and central nervous systems are discussed. © 2021 American Physiological Society. Compr Physiol 11:1-30, 2021. 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