Comparative clinical outcomes of different therapies for traumatic meniscal tears in adults: A protocol for systematic review and network meta-analysis.

Background:Meniscus tears are usually classified into degenerative tears and traumatic tears according to pathogenesis. At present, It is generally believed that traumatic meniscus tears have a high healing potential. In recent years, there are multiple treatments for traumatic meniscus tears, and the most widely used are Inside-Out Technique, Outside-In Technique, All-Inside Technique, biological augmentation of meniscal repair, meniscectomy and non-surgical treatment. However, the functional recovery of the knee joint and the healing of the meniscus after treatment are quite different from the results reported in the literature, which requires more reliable evidence-based medical evidence for reference. The aim of this study is to evaluate all evidence from multiple types of research comparing different therapies for traumatic meniscal tears in adults. Methods：We searched the following electronic databases: EMBASE, The Cochrane Library (the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Cochrane Methodology Register), PubMed, Web of Science (Science and Social Science Citation Index), CNKI, CBM, Wanfang data, and VIP. Search dates from inception to August 10, 2021. There were no language restrictions. We manually searchedd Baidu and Google Scholar to identify randomized controlled studies, non-randomized controlled studies and cohort studies on the treatment of traumatic meniscal tears. Two researchers independently screened the literature, extracted data and evaluated the quality of the studies. Software programs including Microsoft Access, Excel, Stata (Version 15), WinBUGS (Version 1.4.3), and ADDIS (Version 1.16.8) were used to analyze and manipulate data. Results:In this study, Physical function and healing rate are selected as main outcomes, Which including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Lysholm Knee Scoring Scale (LKSS), Knee injury and Osteoarthritis Outcome Score (KOOS), Functional Recovery Scale (FRS), the clinical healing rate. The secondary indexes included total cost, Cost-effective-ness Ratio (CER), Incremental Cost-effectiveness Ratio (ICER), Tegner Activity Scale score, Visual Analogue Scale (VAS), Numerical Rating Scale (NRS), Complications. Conclusions:This systematic review will provide reliable evidence-based for the clinical application of different therapies for traumatic meniscal tears in adults.