肉桂酸
杀菌剂
部分
EC50型
多菌灵
菌丝体
化学
结构-活动关系
立体化学
酒
抗真菌
有机化学
生物
生物化学
体外
植物
微生物学
作者
Kun Zhou,Dongdong Chen,Bin Li,Bingyu Zhang,Fei Miao,Le Zhou
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2017-04-19
卷期号:12 (4): e0176189-e0176189
被引量:34
标识
DOI:10.1371/journal.pone.0176189
摘要
A series of cinnamic acid esters and their derivatives were synthesized and evaluated for antifungal activities in vitro against four plant pathogenic fungi by using the mycelium growth rate method. Structure−activity relationship was derived also. Almost all of the compounds showed some inhibition activity on each of the fungi at 0.5 mM. Eight compounds showed the higher average activity with average EC50 values of 17.4–28.6 μg/mL for the fungi than kresoxim-methyl, a commercial fungicide standard, and ten compounds were much more active than commercial fungicide standards carbendazim against P. grisea or kresoxim-methyl against both P. grisea and Valsa mali. Compounds C1 and C2 showed the higher activity with average EC50 values of 17.4 and 18.5 μg/mL and great potential for development of new plant antifungal agents. The structure−activity relationship analysis showed that both the substitution pattern of the phenyl ring and the alkyl group in the alcohol moiety significantly influences the activity. There exists complexly comprehensive effect between the substituents on the phenyl ring and the alkyl group in the alcohol moiety on the activity. Thus, cinnamic acid esters showed great potential the development of new antifungal agents for plant protection due to high activity, natural compounds or natural compound framework, simple structure, easy preparation, low-cost and environmentally friendly.
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