生物
表观遗传学
形成性评价
胚胎干细胞
诱导多能干细胞
后生
细胞分化
遗传学
表型
细胞生物学
基因表达
基因
DNA甲基化
数学
统计
出处
期刊:Development
[The Company of Biologists]
日期:2017-02-01
卷期号:144 (3): 365-373
被引量:336
摘要
The regulative capability of single cells to give rise to all primary embryonic lineages is termed pluripotency. Observations of fluctuating gene expression and phenotypic heterogeneity in vitro have fostered a conception of pluripotency as an intrinsically metastable and precarious state. However, in the embryo and in defined culture environments the properties of pluripotent cells change in an orderly sequence. Two phases of pluripotency, called naïve and primed, have previously been described. In this Hypothesis article, a third phase, called formative pluripotency, is proposed to exist as part of a developmental continuum between the naïve and primed phases. The formative phase is hypothesised to be enabling for the execution of pluripotency, entailing remodelling of transcriptional, epigenetic, signalling and metabolic networks to constitute multi-lineage competence and responsiveness to specification cues.
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