光动力疗法
癌症研究
光敏剂
缺氧(环境)
纳米医学
前药
细胞毒性T细胞
肿瘤微环境
转移
体内
肿瘤缺氧
化学
化疗
医学
癌症
药理学
体外
材料科学
放射治疗
内科学
氧气
生物
生物化学
光化学
纳米技术
肿瘤细胞
有机化学
纳米颗粒
生物技术
作者
Milan Paul,Asif Mohd Itoo,Balaram Ghosh,Swati Biswas
标识
DOI:10.1016/j.jphotobiol.2022.112627
摘要
Hypoxia is an important pathological hallmark of the tumor microenvironment, associated with metabolic alterations, cell proliferation, aggressiveness, metastasis, and therapy resistance in cancers. Hypoxia impedes the outcome of photodynamic therapy (PDT), which is largely dependent on molecular oxygen to generate cytotoxic 1O2. Here, a near-infrared light activatable, oxygen-generating nanomicellar PDT-chemotherapy system (mPPCPN Ms) constituted of amphiphilic mPEG-PLA, photosensitizer Ce6, and tetravalent platinum prodrug Pt(IV)-diazide was developed for oral squamous cell carcinoma. The polymer conjugate self-assemble to nanosize (115 ± 2.35 nm) micelles, which, upon irradiation (660 nm laser), activated Ce6, and photodecomposed to produce cytotoxic Pt(II), azidyl radical, and molecular oxygen. The strategically fabricated PDT-chemotherapy produced a strong antitumor response in vitro using oral squamous cell carcinoma and in vivo in oral cancer-xenografted mouse models, revealing its significant potential in chemo-photodynamic combination therapy with the benefit of reversing hypoxia.
科研通智能强力驱动
Strongly Powered by AbleSci AI