某种肠道细菌
肝硬化
医学
生物
益生菌
内科学
胃肠病学
免疫学
肠道菌群
细菌
遗传学
作者
Lydie Sparfel,Sandy Ratodiarivony,Élisa Boutet-Robinet,Sandrine Ellero‐Simatos,Anne Jolivet‐Gougeon
标识
DOI:10.1002/mnfr.202300510
摘要
Scope Akkermansia muciniphila (A. muciniphila ) are Gram negative commensal bacteria, degrading mucin in the intestinal mucosa, modulating intestinal permeability and inflammation in the digestive tract, liver, and blood. Some components can promote the relative abundance of A. muciniphila in the gut microbiota, but lower levels of A. muciniphila are more commonly found in people with obesity, diabetes, metabolic syndromes, or inflammatory digestive diseases. Over‐intake of ethanol can also induce a decrease of A. muciniphila , associated with dysregulation of microbial metabolite production, impaired intestinal permeability, induction of chronic inflammation, and production of cytokines. Methods and results Using a PRISMA search strategy, a review is performed on the bacteriological characteristics of A. muciniphila , the factors capable of modulating its relative abundance in the digestive tract and its probiotic use in alcohol‐related liver diseases (alcoholic hepatitis, cirrhosis, hepatocellular carcinoma, hepatic transplantation, partial hepatectomy). Conclusion Several studies have shown that supplementation with A. muciniphila can improve ethanol‐related hepatic pathologies, and highlight the interest in using this bacterial species as a probiotic.
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