橄榄油
医学
核医学
芯(光纤)
放射科
内科学
计算机科学
生物
植物
电信
作者
Vivek Yedavalli,Shingo Kihira,Puja Shahrouki,Omar Hamam,Elham Tavakkol,Mark J. McArthur,Jing Qiao,Fifi Johanna,Amish Doshi,Achala Vagal,Pooja Khatri,Ashok Srinivasan,Neeraj Chaudhary,Mersedeh Bahr-Hosseini,Geoffrey P. Colby,May Nour,Reza Jahan,Gary Duckwiler,Corey Arnold,Jeffrey L. Saver,J Mocco,D Liebeskind,Kambiz Nael
标识
DOI:10.1016/j.jstrokecerebrovasdis.2023.107297
摘要
Background and PurposeCTP is increasingly used to assess eligibility for endovascular therapy (EVT) in patients with large vessel occlusions (LVO). There remain variability and inconsistencies between software packages for estimation of ischemic core. We aimed to use heterogenous data from four stroke centers to perform a comparative analysis for CTP-estimated ischemic core between RAPID (iSchemaView) and Olea (Olea Medical).MethodsIn this retrospective multicenter study, patients with anterior circulation LVO who underwent pretreatment CTP, successful EVT (defined TICI ≥ 2b), and follow-up MRI included. Automated CTP analysis was performed using Olea platform [rCBF < 25% and differential time-to-peak (dTTP)>5s] and RAPID (rCBF < 30%). The CTP estimated core volumes were compared against the final infarct volume (FIV) on post treatment MRI-DWI.ResultsA total of 151 patients included. The CTP-estimated ischemic core volumes (mean ± SD) were 18.7 ± 18.9 mL on Olea and 10.5 ± 17.9 mL on RAPID significantly different (p < 0.01). The correlation between CTP estimated core and MRI final infarct volume was r = 0.38, p < 0.01 for RAPID and r = 0.39, p < 0.01 for Olea. Both software platforms demonstrated a strong correlation with each other (r = 0.864, p < 0.001). Both software overestimated the ischemic core volume above 70 mL in 4 patients (2.6%).ConclusionsSubstantial variation between Olea and RAPID CTP-estimated core volumes exists, though rates of overcalling of large core were low and identical. Both showed comparable core volume correlation to MRI infarct volume.
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