Stereoselectivity in the formation and radical reduction of cyclic bromoacetals, key intermediates for the synthesis of δ-hydroxy- and ε-hydroxy-α-methylcarboxylic acid esters

We report the stereoselectivity in the formation and radical reduction of six- and seven-membered cyclic bromoacetals. The oxidative ring cleavage of the resulting acetals gave the corresponding acyclic δ-hydroxy- and ε-hydroxy-α-methylcarboxylic acid esters.