结合
肽
硝基咪唑
体内
化学
计算生物学
计算机科学
生物化学
组合化学
生物
生物技术
有机化学
数学
数学分析
作者
Katrin Splith,Ralf Bergmann,Jens Pietzsch,Ines Neundorf
出处
期刊:ChemMedChem
[Wiley]
日期:2011-09-29
卷期号:7 (1): 57-61
被引量:20
标识
DOI:10.1002/cmdc.201100401
摘要
Nitroimidazole–peptide conjugates: Attachment of a nitroimidazole unit to a cell-penetrating peptide was used to create conjugates able to target hypoxic tumor tissue. In vivo studies have demonstrated the successful delivery of these conjugates to even less well-perfused hypoxic regions in solid tumors. This approach provides a targeted delivery system with the option to use it as an imaging agent or to conjugate it with therapeutics. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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