Specific Targeting of Hypoxic Tumor Tissue with Nitroimidazole–Peptide Conjugates

Nitroimidazole–peptide conjugates: Attachment of a nitroimidazole unit to a cell-penetrating peptide was used to create conjugates able to target hypoxic tumor tissue. In vivo studies have demonstrated the successful delivery of these conjugates to even less well-perfused hypoxic regions in solid tumors. This approach provides a targeted delivery system with the option to use it as an imaging agent or to conjugate it with therapeutics. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.