癌变
转基因小鼠
转基因
转移
病理
生物
癌症研究
移植
乳腺
恶性转化
癌症
乳腺癌
基因
医学
内科学
遗传学
作者
Jeannie E. Maglione,Drew Moghanaki,Lawrence J.T. Young,Cathyryne K. Manner,Lesley G. Ellies,Simpson Joseph,Benjamin Nicholson,Robert D. Cardiff,Carol L. MacLeod
出处
期刊:PubMed
日期:2001-11-15
卷期号:61 (22): 8298-305
被引量:150
摘要
Mice transgenic for the Polyomavirus middle T (PyV-mT) gene have been widely used to study mammary tumorigenesis and metastasis. Although numerous molecular insights were gained from the analysis of these transgenic malignant tumors, the early events leading to malignant transformation have not been systematically investigated nor has the biological potential of hyperplastic lesions been documented. This paper presents the first comprehensive histopathological characterization of transgenic PyV-mT hyperplasias together with classical transplantation experiments designed to test the growth potential of these lesions. Moreover, stable hyperplastic outgrowth lines were established as a tool to study premalignant PyV-mT-induced hyperplasias in detail. Each line has a different tumor latency, indicating that PyV-mT-induced hyperplasias, like early proliferative lesions seen in the human breast, are heterogeneous with respect to their malignant potential. Our results settle a controversy; they establish that PyV-mT gene expression alone is insufficient to induce tumors and that additional events are required for tumorigenesis and metastasis. These results support the use of PyV-mT transgenic mice as a model for investigating the multistep progression of malignant mammary tumorigenesis and metastasis.
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