作者
Florian van Bömmel,Kerstin Stein,R Heyne,Holger Jon Møller,J. Petersen,Peter Buggisch,Christoph P. Berg,Christoph R. Werner,Stefan Zeuzem,Andreas Stallmach,Anke Herrmann,MF Sprinzl,Annette Grambihler,E. Schott,Julia Benckert,A. Pathil-Warth,Ulrike von Arnim,Verena Keitel,Janina Trauth,KG Simon,Christian Trautwein,Andreas Trein,D Hüppe,Markus Cornberg,Frank Lammert,P Ingilitz,R. Zachoval,Holger Hinrichsen,Alexander Zipprich,Hartwig Klinker,Julian Schulze zur Wiesch,Oana Brosteanu,Anett Schmiedeknecht,Thomas Berg
摘要
Background and aims Discontinuation of long-term suppression of HBV replication with nucleos(t)ide analogues (NUCs) can result in durable immune control of hepatitis B virus (HBV) replication in HBeAg negative patients. We have assessed the effect of NUC discontinuation in HBeAg negative patients in a prospective, multicenter, randomized trial (the Stop-NUC study).