适体
生物分析
纳米技术
化学
灵敏度(控制系统)
微流控
生化工程
生物传感器
工程类
电子工程
材料科学
分子生物学
生物
作者
Ranran Xu,Yongqiang Cheng,Xiaotong Li,Ziwei Zhang,Meijia Zhu,Xiaoxiao Qi,Longyu Chen,Lin Han
标识
DOI:10.1016/j.aca.2022.339893
摘要
With their advantages in specificity, high stability and easy screening, aptamers are becoming increasingly popular recognition elements for biosensor platforms. At the same time, microchips as the new analytical detection platforms have achieved significant growth in the past decades. At present, with the intersection of aptamer and microfluidic technology, aptamer-based high-sensitivity bioanalysis on microchips exhibits a great application potential in biomedical science and environmental fields. In this review, we highlight the recent progress in high-sensitivity bioanalytical applications based on aptamer signal amplification strategies on microchips. Furthermore, the main challenges in the practical application are discussed, and the development in the future is prospected.
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