生物膜
白色念珠菌
壳聚糖
自愈水凝胶
化学
伤口愈合
微生物学
生物材料
海藻酸钠
生物降解
组织工程
体内
钠
细菌
生物医学工程
生物
生物化学
高分子化学
生物技术
医学
遗传学
有机化学
免疫学
作者
Vinit Raj,Chaitany Jayprakash Raorane,Divya Shastri,Seong Cheol Kim,Sang-Kil Lee
标识
DOI:10.1016/j.ijbiomac.2024.129774
摘要
Biofilms developed by microorganisms cause an extremely severe clinical problem that leads to drug failure. Bioactive polymeric hydrogels display potential for controlling the formation of microorganism-based biofilms, but their rapid biodegradability in these biofilm sites is still a major challenge. To overcome this, chitosan (CS), a natural functional biomaterial, has been used because of its effective penetrability in the cell wall of microorganisms; however, its fast biodegradability has restricted its further use. Hence, in this study, to improve the stability of CS and increase its penetration retention inside a biofilm, grafted CS was prepared and then crosslinked with sodium alginate (SA) to synthesize CS-poly(MA-co-AA)SA hydrogel via a free radical grafting method, therefore enhancing its antibiofilm efficiency against biofilms. The prepared hydrogel demonstrated excellent effectiveness against (≥90 % inhibition) biofilms of Candida albicans. Additionally, in vitro and in vivo safety assays established that the prepared hydrogel can be used in a biofilm microenvironment and might reduce drug resistance burden owing to its long-term antibiofilm effect and improved CS stability at the biofilm site. Furthermore, in vitro wound healing outcomes of hydrogel indicated its potential application for chronic wound treatment. This research opens a new advanced strategy for biofilm-associated infection treatment, including wound treatment.
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