神经保护
益生菌
萧条(经济学)
焦虑
肠道菌群
肠-脑轴
高架加迷宫
胃肠道
医学
生物
药理学
内科学
精神科
免疫学
遗传学
细菌
宏观经济学
经济
作者
Longgang Jia,Ling Xiao,Yao Fu,Zhifeng Shao,Zhaoxuan Jing,Jiahu Yuan,Yizhen Xie,Jianhua Guo,Yanping Wang,Weitao Geng
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2023-01-01
被引量:1
摘要
Anxiety- and depression-like behaviors are commonly observed clinical features of depression and many other mental disorders. Recent evidence has revealed the crucial role of the microbiota-gut-brain axis in the bidirectional communication between the gastrointestinal tract and the central nervous system. Supplementation with psychobiotics may provide a novel approach for the adjunctive treatment of mental disorders by regulating the intestinal microecology. We isolated and identified a novel probiotic, Lactiplantibacillus plantarum D-9 (D-9), from traditional Chinese fermented foods in our previous work, which exhibited a high yield of gamma-aminobutyric acid (GABA). Herein, it was proved that the oral administration of D-9 could alleviate the depression- and anxiety-like behaviors of Chronic Unpredicted Mild Stress (CUMS) mice, and show non-toxicity or side-effects in the mice. Physiological and biochemical analyses demonstrated that D-9 regulated tryptophan metabolism, the HPA-axis and inflammation in CUMS mice. Moreover, D-9 modulated the structure and composition of the gut microbiota, leading to an increase in the relative abundance of Ligilactobacillus murinus and Lactobacillus johnsonii, and a decrease in the levels of Kineothrix alysoides and Helicobacter bilis compared to those in CUMS mice. Our work demonstrates that D-9 alleviated anxiety- and depression-like disorders in CUMS mice by modulating tryptophan metabolism and the gut microbiota. These findings provide an innovative strategy for the intervention and treatment of depressive disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI