Hydrothermal assisted ultrasonic synthesis of MgFe-LDH as a simple and eco-friendly method for electrochemical detection of vitamin B6

A new eco-friendly electrochemical sensor with high sensitivity and selectivity has been introduced in the present work. The proposed sensor is a MgFe-layered double hydroxide (MgFe -LDH) synthesizing via a very simple method. This sensor for the first time was used to determine pyridoxine hydrochloride (vitamin B6) using the differential pulse voltammetry (DPV) technique. The morphology and chemical composition of the MgFe-LDH was recognized using field emission scanning electron microscope (FESEM), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), and Brunauer-Emmett-Teller (BET). Under optimal conditions, the calibration curve was plotted using the DPV technique. The limit of detection (LOD) was 131 nM and a linear range of 900 nM–2300 μM was obtained for vitamin B6 oxidation. Therefore, the method is sensitive, simple, and specific with a short analysis time, and the main advantages of this sensor are easy synthesis, low detection limit, excellent stability, repeatability, and good selectivity in vitamin B6. This sensor has been successfully utilized in determining vitamin B6 in human plasma, rice flour, and tablet samples.