材料科学
去细胞化
再生(生物学)
细胞外基质
复合数
复合材料
组织工程
粘附
制作
弹性体
生物医学工程
电导率
化学
细胞生物学
医学
生物化学
替代医学
物理化学
病理
生物
作者
Gülçin Günal,Dinçer Gökcen,Halil Murat Aydin
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2023-10-02
卷期号:6 (10): 4100-4104
标识
DOI:10.1021/acsabm.3c00557
摘要
Myocardial tissue engineering strategies such as fabrication of cardiac patches for tissue regeneration offer various solutions for the loss of function developed due to myocardial infarction. Here, we combined the hybrid structure (previously obtained and combined decellularized myocardium grafts with poly(glycerol-sebacate) polymer) with multiwalled carbon nanotubes (MWCNTs) to provide the essential characteristics for cardiac tissue regeneration. MWCNTs were doped in the cross-linked structure, and the conductivity and Young’s modulus of the composite elastomer were found as 5 × 10–3 ± 1 × 10–3 S/m and 374 ± 75.8 kPa, respectively. The cell-material interaction was evaluated, and composite structures supported cell adhesion and showed no cytotoxic effect.
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