Total body bone mineral density and various spinal disorders: a Mendelian randomization study

医学 孟德尔随机化 内科学 优势比 置信区间 椎管狭窄 骨矿物 肿瘤科 胃肠病学 外科 骨质疏松症 遗传学 生物 基因型 遗传变异 基因 腰椎
作者
Qingyu Jiang,Haihao Gao,Xudong Shi,Yan Wu,Wentao Ni,Aijia Shang
出处
期刊:Frontiers in Endocrinology [Frontiers Media]
卷期号:14 被引量:1
标识
DOI:10.3389/fendo.2023.1285137
摘要

Introduction Observational studies have yielded inconsistent findings regarding the correlation between bone mineral density (BMD) and various spinal disorders. To explore the relationship between total-body BMD and various spinal disorders further, we conducted a Mendelian randomization analysis to assess this association. Methods Two-sample bidirectional Mendelian randomization (MR) analysis was employed to investigate the association between total-body BMD and various spinal disorders. The inverse-variance weighted (IVW) method was used as the primary effect estimate, and additional methods, including weighted median, MR-Egger, simple mode, and weighted mode, were used to assess the reliability of the results. To examine the robustness of the data further, we conducted a sensitivity analysis using alternative bone-density databases, validating the outcome data. Results MR revealed a significant positive association between total-body BMD and the prevalence of spondylosis and spinal stenosis. When total-body BMD was considered as the exposure factor, the analysis demonstrated an increased risk of spinal stenosis (IVW odds ratio [OR] 1.23; 95% confidence interval [CI], 1.14–1.32; P < 0.001) and spondylosis (IVW: OR 1.24; 95%CI, 1.16–1.33; P < 0.001). Similarly, when focusing solely on heel BMD as the exposure factor, we found a positive correlation with the development of both spinal stenosis (IVW OR 1.13, 95%CI, 1.05–1.21; P < 0.001) and spondylosis (IVW OR 1.10, 95%CI, 1.03–1.18; P = 0.0048). However, no significant associations were found between total-body BMD and other spinal disorders, including spinal instability, spondylolisthesis/spondylolysis, and scoliosis (P > 0.05). Conclusion This study verified an association of total-body BMD with spinal stenosis and with spondylosis. Our results imply that when an increasing trend in BMD is detected during patient examinations and if the patient complains of numbness and pain, the potential occurrence of conditions such as spondylosis or spinal stenosis should be investigated and treated appropriately.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
俞孤风完成签到,获得积分10
1秒前
potato_bel完成签到,获得积分10
2秒前
2秒前
勤恳的德地完成签到,获得积分10
3秒前
HY完成签到,获得积分10
3秒前
3秒前
anny2022完成签到,获得积分10
4秒前
LGZ完成签到 ,获得积分10
4秒前
Qing完成签到 ,获得积分10
5秒前
hebhm完成签到,获得积分10
5秒前
上官若男应助科研通管家采纳,获得10
5秒前
Jasper应助科研通管家采纳,获得10
6秒前
laber应助科研通管家采纳,获得30
6秒前
英姑应助科研通管家采纳,获得10
6秒前
cdercder应助科研通管家采纳,获得10
6秒前
cdercder应助科研通管家采纳,获得10
6秒前
6秒前
七龙珠完成签到,获得积分10
6秒前
独特的凝云完成签到 ,获得积分10
7秒前
高木同学发布了新的文献求助10
7秒前
平常的毛豆应助zzl1111采纳,获得10
8秒前
manmanzhong完成签到 ,获得积分10
8秒前
伶俐碧萱完成签到 ,获得积分10
8秒前
外套waitlen发布了新的文献求助10
9秒前
简单的思菱完成签到 ,获得积分10
10秒前
xxj完成签到 ,获得积分10
11秒前
我瞎蒙完成签到,获得积分10
11秒前
12秒前
喜悦的板凳完成签到 ,获得积分10
13秒前
张小度ever完成签到 ,获得积分10
13秒前
14秒前
钟sss完成签到 ,获得积分10
14秒前
踏实采波完成签到,获得积分10
16秒前
16秒前
kaka发布了新的文献求助10
16秒前
gaga发布了新的文献求助10
18秒前
zzl1111完成签到,获得积分10
18秒前
外套waitlen完成签到,获得积分20
18秒前
mrjohn完成签到,获得积分10
19秒前
钟sss关注了科研通微信公众号
20秒前
高分求助中
Technologies supporting mass customization of apparel: A pilot project 600
Izeltabart tapatansine - AdisInsight 500
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
Epigenetic Drug Discovery 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3815941
求助须知:如何正确求助?哪些是违规求助? 3359417
关于积分的说明 10402560
捐赠科研通 3077261
什么是DOI,文献DOI怎么找? 1690255
邀请新用户注册赠送积分活动 813693
科研通“疑难数据库(出版商)”最低求助积分说明 767743