银屑病
免疫学
免疫系统
特应性皮炎
细胞毒性T细胞
炎症
人口
医学
免疫
T细胞
淋巴瘤
癌症
生物
内科学
体外
环境卫生
生物化学
作者
Joanna Chojnacka‐Purpurowicz,Agnieszka Owczarczyk‐Saczonek,Bogusław Nedoszytko
摘要
Gamma delta (γδ) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, γδ T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. γδ T cells are found in epithelial tissues, where many cancers develop. There, they participate in antitumor immunity as cytotoxic cells or as immune coordinators. γδ T cells also participate in host defense, immune surveillance, and immune homeostasis. The aim of this review is to present the importance of γδ T cells in physiological and pathological diseases, such as psoriasis, atopic dermatitis, autoimmune diseases, cancer, and lymphoma.
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