The multifaceted roles of phosphoethanolamine-modified lipopolysaccharides: from stress response and virulence to cationic antimicrobial resistance

脂质A 生物 毒力 细菌外膜 细菌 抗生素耐药性 微生物学 抗菌剂 基因 粘菌素 抗菌肽 生物化学 遗传学 大肠杆菌
作者
Anna Schumann,Ahmed Gaballa,Martin Wiedmann
出处
期刊:Microbiology and Molecular Biology Reviews [American Society for Microbiology]
被引量:1
标识
DOI:10.1128/mmbr.00193-23
摘要

SUMMARY Lipopolysaccharides (LPS) are an integral part of the outer membrane of Gram-negative bacteria and play essential structural and functional roles in maintaining membrane integrity as well as in stress response and virulence. LPS comprises a membrane-anchored lipid A group, a sugar-based core region, and an O-antigen formed by repeating oligosaccharide units. 3-Deoxy-D- manno -octulosonic acid-lipid A (Kdo 2 -lipid A) is the minimum LPS component required for bacterial survival. While LPS modifications are not essential, they play multifaceted roles in stress response and host-pathogen interactions. Gram-negative bacteria encode several distinct LPS-modifying phosphoethanolamine transferases (PET) that add phosphoethanolamine (pEtN) to lipid A or the core region of LPS. The pet genes differ in their genomic locations, regulation mechanisms, and modification targets of the encoded enzyme, consistent with their various roles in different growth niches and under varied stress conditions. The discovery of mobile colistin resistance genes, which represent lipid A-modifying pet genes that are encoded on mobile elements and associated with resistance to the last-resort antibiotic colistin, has led to substantial interest in PETs and pEtN-modified LPS over the last decade. Here, we will review the current knowledge of the functional diversity of pEtN-based LPS modifications, including possible roles in niche-specific fitness advantages and resistance to host-produced antimicrobial peptides, and discuss how the genetic and structural diversities of PETs may impact their function. An improved understanding of the PET group will further enhance our comprehension of the stress response and virulence of Gram-negative bacteria and help contextualize host-pathogen interactions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
8秒前
8秒前
10秒前
yuanyijie发布了新的文献求助10
12秒前
rabbit发布了新的文献求助10
14秒前
PLAGH221发布了新的文献求助10
14秒前
14秒前
15秒前
16秒前
xyz完成签到,获得积分10
17秒前
糕糕发布了新的文献求助10
19秒前
20秒前
21秒前
RENAISSANCE111完成签到,获得积分10
22秒前
刻骨铭心发布了新的文献求助10
23秒前
靓仔完成签到,获得积分10
24秒前
吴1发布了新的文献求助10
25秒前
25秒前
CipherSage应助科研通管家采纳,获得10
26秒前
SciGPT应助科研通管家采纳,获得10
26秒前
26秒前
科研通AI5应助RENAISSANCE111采纳,获得10
26秒前
26秒前
26秒前
科研通AI2S应助wenfeisun采纳,获得10
27秒前
科研通AI2S应助wenfeisun采纳,获得10
27秒前
霸霸斌完成签到 ,获得积分10
27秒前
yu发布了新的文献求助10
27秒前
贝贝完成签到 ,获得积分10
28秒前
30秒前
123发布了新的文献求助10
30秒前
但大图完成签到 ,获得积分10
33秒前
大大怪发布了新的文献求助10
33秒前
欣欣完成签到,获得积分10
37秒前
LeiZha完成签到,获得积分10
37秒前
科研通AI2S应助123采纳,获得10
37秒前
梦想家完成签到 ,获得积分10
40秒前
顾矜应助月球上的陈医生采纳,获得10
42秒前
TheSilencer完成签到 ,获得积分10
45秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Platinum-group elements : mineralogy, geology, recovery 260
Geopora asiatica sp. nov. from Pakistan 230
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3780433
求助须知:如何正确求助?哪些是违规求助? 3325869
关于积分的说明 10224534
捐赠科研通 3040916
什么是DOI,文献DOI怎么找? 1669147
邀请新用户注册赠送积分活动 799013
科研通“疑难数据库(出版商)”最低求助积分说明 758653