Quinoxaline-probe embedded injectable fluorogenic hydrogels: Comparative detection of mesitylene in guar gum and i-carrageenan hydrogels

The innovation of novel chemosensor probes for the recognition of trace volatile organic compounds is critical due to their hazardous effect on the environment and human health. A nitro-group integrated quinoxaline probe with a profound discriminative fluorescence 'turn-on' response to mesitylene was fabricated into guar gum and i-carrageenan, two biopolymer-based hydrogel matrices, to develop compact, portable fluorogenic hydrogel sensors and assess their fluorescence properties. A comparative characterization-based analysis of native, probe-associated, and probe-analyte-associated hydrogels, (comprising of FT-IR, XRD, TGA) was investigated to ascertain the overall compatibility of the hydrogel-based sensors for use as a smart rapid detection tool. Dynamic rheological measurements also validated the mechanical stability and robustness of the developed hydrogel matrices. Fluorescence spectroscopic investigations yielded promising results of 0.15 ppm limit of detection (LOD) in guar gum and 0.29 ppm LOD in i-carrageenan hydrogels respectively. FESEM and Fluorescence microscopy studies represented the morphological variations of the hydrogel sensors on interaction with mesitylene. The practical feasibility of the chemosensor in hydrogel form for mesitylene detection in the vapor phase was also explored. Probe-embedded hydrogels with injectable property was shown, depicting its use as security ink for information encryption functions. This approach of incorporating chemosensors into biobased hydrogel networks has the potential to broaden its opportunities in the field of chemical, biomedical, and environmental sensing sectors.