The effects of regular exercise on cognitive and cardiometabolic health in testicular cancer survivors subjected to platinum‐based chemotherapy

Abstract Background Platinum‐based chemotherapy provides curative treatment to more than 95% of patients with testicular germ cell tumor but it has negative cardiometabolic and neurological effects. Regular exercise can alleviate late chemotherapy‐related toxicities. We examined the impact of a 6‐month supervised aerobic‐strength training on cognitive and cardiometabolic health and residual level of platinum in cancer survivors. Methods Twenty‐eight middle‐aged (42.1 ± 7.6 years) testicular germ cell tumor survivors subjected to platinum‐based chemotherapy (1–8 cycles, 0–24 years ago) were recruited into exercise ( n = 20) and control ( n = 8) groups. Effects of 6‐month exercise training on the whole‐body and muscle metabolism, cognitive functions, cardiopulmonary fitness, residual plasma platinum, and plasma adiponectin were examined. Results Exercise intervention improved cardiopulmonary fitness and cognitive functions, reduced residual plasma platinum, visceral adiposity and muscle lipids, improved glucose (glycosylated hemoglobin) and lipid (high‐density lipoprotein cholesterol) metabolism, and enhanced dynamics of muscle post‐exercise phosphocreatine recovery. Exercise‐related decline in plasma platinum was paralleled by decline of muscle glycerophosphocholines and by the enhanced metabolic flexibility during low‐intensity exercise, and predicted training‐induced increase in cognitive functions. Conclusions The 6‐month exercise intervention resulted in improved cognitive and cardiometabolic health in testicular germ cell tumor survivors, which was paralleled by reduced plasma platinum, providing evidence that structured supervised exercise brings multiple health benefits to testicular germ cell tumor survivors.