Elucidating the mechanism and origin of diastereoselectivity in scandium-catalyzed β-C(sp3)–H activation and transformation of an aliphatic aldimine

The mechanism and origin of regio- and diastereoselectivity in the reaction of divergent [3 + 2] annulation of aliphatic aldimines with alkenes by scandium-catalyzed β-C(sp 3 )–H activation have been revealed in detail using DFT calculations.