制作
对偶(语法数字)
图层(电子)
纳米纤维
双层
材料科学
纳米技术
生物医学工程
化学
工程类
医学
病理
艺术
替代医学
文学类
作者
Xiaofeng Wang,Zifan Zou,Kecheng Li,Cuihong Ren,Xiaorong Yu,Yang Zhang,Peng Zhao,Shujie Yan,Qian Li
标识
DOI:10.1016/j.colsurfb.2024.113988
摘要
Confronted with the profound threat of cardiovascular diseases to health, vascular tissue engineering presents potential beyond the limitations of autologous and allogeneic grafts, offering a promising solution. This study undertakes an initial exploration into the impact of a natural active protein, elastin, on vascular cell behavior, by incorporating with polycaprolactone to prepare fibrous tissue engineering scaffold. The results reveal that elastin serves to foster endothelial cell adhesion and proliferation, suppress smooth muscle cell proliferation, and induce macrophage polarization. Furthermore, the incorporation of elastin contributes to heightened scaffold strength, compliance, and elongation, concomitantly lowering the elastic modulus. Subsequently, a bilayer oriented polycaprolactone (PCL) scaffold infused with elastin is proposed. This design draws inspiration from the cellular arrangement of native blood vessels, leveraging oriented fibers to guide cell orientation. The resulting fiber scaffold exhibits commendable mechanical properties and cell infiltration capacity, imparting valuable insights for the rapid endothelialization of vascular scaffolds.
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