异氰
化学
芳基
卤化物
烷基
催化作用
选择性
组合化学
偶联反应
联轴节(管道)
药物化学
有机化学
材料科学
冶金
作者
Anne‐Marie Dechert‐Schmitt,Michelle R. Garnsey,Hanna M. Wisniewska,J. A. H. Murray,Taegyo Lee,Daniel W. Kung,Neal W. Sach,Donna G. Blackmond
标识
DOI:10.1021/acscatal.9b00581
摘要
A one-pot, four-component Pd-catalyzed coupling has been developed for the synthesis of unsymmetrical 1,2-diketones from aryl halides and alkyl zincs employing tert-butyl isocyanide as a CO source. The intermediate 1,2-diketones have been elaborated to quinoxalines. Mechanistic studies help to rationalize the high selectivity for the bis- vs monoinsertion product.
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