光热治疗
杰纳斯
光热效应
膜
纳米技术
材料科学
生物物理学
癌细胞
发热
化学
癌症
遗传学
生物化学
生物
热力学
物理
作者
Mingjun Xuan,Jianzhong Shao,Changyong Gao,Wei Wang,Luru Dai,Qiang He
标识
DOI:10.1002/anie.201806759
摘要
Abstract We report a near‐infrared (NIR) light‐powered Janus mesoporous silica nanomotor (JMSNM) with macrophage cell membrane (MPCM) cloaking that can actively seek cancer cells and thermomechanically percolate cell membrane. Upon exposure to NIR light, a heat gradient across the Janus boundary of the JMSNMs is generated by the photothermal effect of the Au half‐shells, resulting in a self‐thermophoretic force that propels the JMSNMs. In biological medium, the MPCM camouflaging can not only prevent dissociative biological blocks from adhering to JMSNMs but also improve the seeking sensitivity of the nanomotors by specifically recognizing cancer cells. The biofriendly propulsion and recognition capability enable JMSNMs to achieve the active seeking and bind to the membrane of cancer cells. Subsequent illumination with NIR then triggers the photothermal effect of MPCM@JMSNMs to thermomechanically perforate the cytomembranes for guest molecular injection. This approach integrates the functions of active seeking, cytomembranes perforating, and thermomechanical therapy in nanomotors, which may pave the way to apply self‐propelled motors in biomedical fields.
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