生物碱
体内
离体
生物
化学
立体化学
植物
生物技术
作者
Guangjie Zhang,Tian Shen,Xiaolan Chen,Chunhua Ge,Bin Li,Ying Tian,Min Li,Sifan Liu,Ziming Xia,Haixia Li,Fengjun Xiao,Shu-Chen Liu
出处
期刊:Fitoterapia
[Elsevier]
日期:2023-07-01
卷期号:168: 105544-105544
被引量:2
标识
DOI:10.1016/j.fitote.2023.105544
摘要
A new alkaloid, Orychophragine D (1), together with three known alkaloids, were isolated from the seeds of Orychophragmus violaceus. Orychophragine D represented the first example of 2-piperazinone fused 5-azacytosine skeleton. Their structures and absolute configurations were determined by spectroscopic analyses and X-ray crystallography. Compared to Ex-RAD, compound 1 exhibited a significant radioprotective activity on cell survival of irradiated HUVEC. In vivo experiments showed that 1 not only remarkably enhanced the survival of irradiated mice in 30 days, but also significantly promoted the recovery of the blood system of irradiated mice. These results suggested that 1 was valuable for further research as promising radioprotectors.
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