烯丙基重排
化学
分子内力
布朗斯特德-洛瑞酸碱理论
催化作用
取代反应
替代(逻辑)
烯丙醇
有机化学
药物化学
组合化学
计算机科学
程序设计语言
作者
Yunfan Li,Yu-Ting Xi,Kai Hu,Qitao Tan,Chang‐Hua Ding,Bin Xu
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2024-04-08
摘要
Brønsted acid-catalyzed intramolecular allylic substitution reaction of secondary and tertiary allylic alcohols has been developed. A variety of 2-vinylchromans were efficiently prepared in moderate to excellent yields. The given method features wide substrate scope, operational simplicity, metal-free, and mild reaction conditions. The practicability of the method was demonstrated by the gram-scale reaction and further derivations of the product. Catalytic asymmetric reaction was preliminarily studied.
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