类风湿性关节炎
医学
药物输送
纳米载体
关节炎
免疫系统
药品
免疫学
药理学
纳米技术
材料科学
作者
Hemant Singh,Akiyoshi Dan,Mukesh Kumar Kumawat,Vaishali Pawar,Deepak S. Chauhan,Ajeet Kaushik,Dhiraj Bhatia,Rohit Srivastava,Mukesh Dhanka
出处
期刊:Biomaterials
[Elsevier]
日期:2023-11-01
卷期号:: 122390-122390
标识
DOI:10.1016/j.biomaterials.2023.122390
摘要
Rheumatoid arthritis (RA) is one of the most prevalent life-long autoimmune diseases with an unknown genesis. It primarily causes chronic inflammation, pain, and synovial joint-associated cartilage and bone degradation. Unfortunately, limited information is available regarding the etiology and pathogenesis of this chronic joint disorder. In the few last decades, an improved understanding of RA pathophysiology about key immune cells, antibodies, and cytokines has inspired the development of several anti-rheumatic drugs and biopharmaceuticals to act on RA-affected joints. However, life-long frequent systemic high doses of commercially available drugs are currently a limiting factor in the efficient management of RA. To address this issue, various single and double-barrier intra-articular drug delivery systems (IA-DDSs) such as nanocarriers, microparticles, hydrogels, and particles-hybrid hydrogel composite have been developed which can exclusively target the RA-affected joint cavity and release the precisely controlled therapeutic drug concentration for prolonged time whilst avoiding the systemic toxicity. This review provides a comprehensive overview of the pathogenesis of RA and discusses the rational design and development of biomaterials-based novel IA-DDs, ranging from conventional to advanced systems, for improved treatment of RA. Therefore, this review aims to unravel the pathophysiology of rheumatoid arthritis and explore cutting-edge IA-DD strategies exploiting biomaterials. It offers researchers a consolidated and up-to-date resource platform to analyze existing knowledge, identify research gaps, and contribute to the scientific literature.
科研通智能强力驱动
Strongly Powered by AbleSci AI