转录组
癌症
DNA甲基化
免疫系统
癌症研究
胶质瘤
基因
生物
医学
免疫学
肿瘤科
基因表达
内科学
遗传学
作者
Liying Song,Feng Jiang,Yu Tian,Xiaolan Cao,Minxia Zhu,Jie Zhang,Xiaoping Wang,Langmei Deng
摘要
Abstract Background Colony‐stimulating factor 3 receptor (CSF3R) has been demonstrated to be associated with various hematological tumors, especially chronic neutrophilic leukemia; however, the detailed roles of CSF3R in other cancers remain to be explored. Methods In the present study, we systematically analyzed the expression profiles of CSF3R in pan‐cancer by comprehensive bioinformatics databases, such as Tumor Immune Estimation Resource, version 2 (TIMER2.0), Gene Expression Profiling Interactive Analysis, version 2 (GEPIA2.0), etc. GEPIA2.0 was also used to analyze the relationship between CSF3R expression and patients' survival prognosis. Results We found that the high expression of CSF3R was associated with a poor prognosis in the brain tumor patients, such as brain lower grade glioma and glioblastoma multiforme. In addition, we further investigated the genetic mutation and DNA methylation level of CSF3R in multiple cancers. Immune infiltration analysis showed that CSF3R expression was positively correlated with a variety of tumor‐infiltrating immune cells in most cancers. Single cell sequencing indicated that CSF3R levels were correlated with several cancer‐associated pathways, such as DNA damage, cell invasion, and stemness. Conclusions Taken together, the role of CSF3R in multiple cancers might reveal its potential as a novel prognostic biomarker and therapeutic target for cancer patients.
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