UniProt公司
计算机科学
数据库
蛋白质基因组学
资源(消歧)
数据挖掘
情报检索
基因组学
生物
基因
计算机网络
生物化学
基因组
作者
Pieter Verschaffelt,Alessandro Tanca,Marcello Abbondio,Tim Van Den Bossche,Tibo Vande Moortele,Peter Dawyndt,Lennart Martens,Bart Mesuere
标识
DOI:10.1021/acs.jproteome.3c00091
摘要
Unipept Desktop 2.0 is the most recent iteration of the Unipept Desktop tool that adds support for the analysis of metaproteogenomics datasets. Unipept Desktop now supports the automatic construction of targeted protein reference databases that only contain proteins (originating from the UniProtKB resource) associated with a predetermined list of taxa. This improves both the taxonomic and functional resolution of a metaproteomic analysis and yields several technical advantages. By limiting the proteins present in a reference database, it is also possible to perform (meta)proteogenomics analyses. Since the protein reference database resides on the user's local machine, they have complete control over the database used during an analysis. Data no longer need to be transmitted over the Internet, decreasing the time required for an analysis and better safeguarding privacy-sensitive data. As a proof of concept, we present a case study in which a human gut metaproteome dataset is analyzed with Unipept Desktop 2.0 using different targeted databases based on matched 16S rRNA gene sequencing data.
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