吞噬作用
先天免疫系统
免疫检查点
封锁
化学
癌症研究
免疫疗法
免疫系统
免疫学
生物
受体
生物化学
作者
Wen Song,Fan Yang,Hang Yang,Yi Xu,Shujun Song,Yan Meng,Sitian Wei,Tao Wan,Ying Zhou,Bin Zhou,Jing Kuang,Tao Yu,Wen‐Xiu Qiu
标识
DOI:10.1021/acs.jmedchem.2c01351
摘要
Compared to the activation of acquired immunity by the immune checkpoint blockade, the activation of innate immunity via anti-phagocytosis checkpoint blockade could significantly increase the beneficiary population of immunotherapy. However, the activation of innate immunity and the occurrence of phagocytosis are only accomplished when the interaction between pro-phagocytosis signals and anti-phagocytosis signals is realized. Herein, a versatile nanoplatform (DHMR) based on mesoporous silicon nanoparticles (MSNPs) has been constructed. Two drugs, doxorubicin, a chemotherapeutic drug which could initiate tumor cells to release pro-phagocytosis signals, and RRx-001, an immunoadjuvant that could effectively implement the anti-phagocytosis checkpoint blockade, were loaded in MSNPs. Further decoration of hyaluronic acid encapsulation endows DHMR with the function of tumor targeting and long circulation. Ultimately, the DHMR system could efficiently and accurately target tumor tissue, release the drugs in the tumor microenvironment, achieve the activation of innate immunity, and finally dramatically inhibit the growth and metastasis of tumor cells.
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