过氧化氢
癌症治疗
联合疗法
芬顿反应
化学
癌症
癌症治疗
癌症研究
医学
药理学
生物化学
内科学
作者
Minghui Li,Wen Zhang,Xiangdong Xu,Guoying Li,Mengfei Dong,Kaoxiang Sun,Peng Zhang
标识
DOI:10.3389/fphar.2022.1065438
摘要
Chemodynamic therapy (CDT), a newly developed approach for cancer treatment, can convert hydrogen peroxide (H 2 O 2 ) into toxic hydroxyl radicals (•OH) by using Fenton/Fenton-like reaction to kill tumor cells. However, due to the complexity of the intracellular environment of tumor cells, the therapeutic efficacy of CDT was severely restricted. Recently, combination therapy strategies have become popular approaches for tumor treatment, and there are numerous studies have demonstrated that the CDT-based combination strategies can significantly improve the anti-tumor efficiency of CDT. In this review, we outline some of the recent progress in cancer chemodynamic therapy from 2020, and discuss the progress in the design of nanosystems for CDT synergistic combination therapies.
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