三氯蔗糖
T细胞
细胞内
细胞
细胞生物学
自身免疫
CD8型
化学
免疫系统
生物
免疫学
生物化学
食品科学
作者
Fabio Zani,Julianna Blagih,Tim Gruber,Michael D. Buck,Nicholas Jones,Marc Hennequart,Clare L. Newell,Steven E. Pilley,Pablo Soro-Barrio,Gavin Kelly,Nathalie Legrave,Eric C. Cheung,Ian S. Gilmore,Alex P. Gould,Cristina García‐Cáceres,Karen H. Vousden
出处
期刊:Nature
[Springer Nature]
日期:2023-03-15
卷期号:615 (7953): 705-711
被引量:24
标识
DOI:10.1038/s41586-023-05801-6
摘要
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years1. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners2-5. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8+ T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders.
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