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Anatomical Substrates of Rapid Eye Movement Sleep Rebound in a Rodent Model of Post-sevoflurane Sleep Disruption

七氟醚 睡眠剥夺 中脑 医学 快速眼动睡眠 睡眠(系统调用) 麻醉 前脑 c-Fos公司 运动前神经元活动 神经科学 基底前脑 内分泌学 内科学 眼球运动 生物 昼夜节律 中枢神经系统 基因表达 计算机科学 基因 操作系统 生物化学
作者
Navya Atluri,Elżbieta Dulko,Michal Jedrusiak,Joanna Klos,Hari Prasad Osuru,Eric M. Davis,Mark P. Beenhakker,Jaideep Kapur,Zhiyi Zuo,Nadia Lunardi
出处
期刊:Anesthesiology [Lippincott Williams & Wilkins]
卷期号:140 (4): 729-741 被引量:1
标识
DOI:10.1097/aln.0000000000004893
摘要

Background Previous research suggests that sevoflurane anesthesia may prevent the brain from accessing rapid eye movement (REM) sleep. If true, then patterns of neural activity observed in REM-on and REM-off neuronal populations during recovery from sevoflurane should resemble those seen after REM sleep deprivation. In this study, the authors hypothesized that, relative to controls, animals exposed to sevoflurane present with a distinct expression pattern of c-Fos, a marker of neuronal activation, in a cluster of nuclei classically associated with REM sleep, and that such expression in sevoflurane-exposed and REM sleep–deprived animals is largely similar. Methods Adult rats and Targeted Recombination in Active Populations mice were implanted with electroencephalographic electrodes for sleep–wake recording and randomized to sevoflurane, REM deprivation, or control conditions. Conventional c-Fos immunohistochemistry and genetically tagged c-Fos labeling were used to quantify activated neurons in a group of REM-associated nuclei in the midbrain and basal forebrain. Results REM sleep duration increased during recovery from sevoflurane anesthesia relative to controls (157.0 ± 24.8 min vs. 124.2 ± 27.8 min; P = 0.003) and temporally correlated with increased c-Fos expression in the sublaterodorsal nucleus, a region active during REM sleep (176.0 ± 36.6 cells vs. 58.8 ± 8.7; P = 0.014), and decreased c-Fos expression in the ventrolateral periaqueductal gray, a region that is inactive during REM sleep (34.8 ± 5.3 cells vs. 136.2 ± 19.6; P = 0.001). Fos changes similar to those seen in sevoflurane-exposed mice were observed in REM-deprived animals relative to controls (sublaterodorsal nucleus: 85.0 ± 15.5 cells vs. 23.0 ± 1.2, P = 0.004; ventrolateral periaqueductal gray: 652.8 ± 71.7 cells vs. 889.3 ± 66.8, P = 0.042). Conclusions In rodents recovering from sevoflurane, REM-on and REM-off neuronal activity maps closely resemble those of REM sleep–deprived animals. These findings provide new evidence in support of the idea that sevoflurane does not substitute for endogenous REM sleep. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New
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