内分泌学
内科学
氧化应激
化学
梓醇
促肾上腺皮质激素
脂质过氧化
皮质酮
神经保护
一氧化氮合酶
一氧化氮
谷胱甘肽
海马体
超氧化物歧化酶
激素
医学
生物化学
糖苷
酶
有机化学
作者
Lingling Song,Xiaohui Wu,Junming Wang,Yuechen Guan,Yueyue Zhang,Mingzhu Gong,Yanmei Wang,Bingyin Li
标识
DOI:10.1016/j.brainresbull.2021.09.002
摘要
This study aimed to investigate the antidepressant effect and mechanism of catalpol on corticosterone (CORT)-induced depressive-like behavior in mice for the first time. As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of nuclear factor kappa-B (NF-κB) in the hippocampus and frontal cortex, and down-regulated the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2). Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (interleukin-1β, tumor necrosis factor-α, nitric oxide synthase, and nitric oxide) and lipid peroxidation product malondialdehyde, and attenuated the levels of antioxidants including reduced glutathione, glutathione S-transferase, total superoxide dismutase, and heme oxygenase-1 in the mouse hippocampus and frontal cortex. On the contrary, catalpol administration markedly suppressed the abnormalities of the above indicators. From the overall results, this study displayed that catalpol exerted a beneficial effect on CORT-induced depressive-like behavior in mice possibly via the inhibition of hypothalamus-pituitary-adrenal (HPA) axis hyperactivity, central inflammation and oxidative damage at least partially through dual regulation of NF-κB and Nrf2.
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