The Total Synthesis of Dehexyl-deisovaleryloxy-antimycin A1

Abstract A biologically active prototype of antimycin A series has been synthesized. The dilactone moiety was synthesized from a masked l-threonine and γ-hydroxyvalerate and condensed with an O-masked derivative of 3-nitrosalicylic acid N-hydroxysuccinimide ester. Hydrogenation followed by formylation afforded the anti-fungal substance. This synthesis established a possible general synthetic pathway to the members of antimycin A.