化学
酰化
肟
产量(工程)
串联
键裂
有机化学
光化学
催化作用
复合材料
冶金
材料科学
作者
Yichen Liu,Pu Chen,Xue-Jiao Li,Biquan Xiong,Kewen Tang,Pengfei Huang
标识
DOI:10.1021/acs.joc.1c03100
摘要
Heterocyclic compounds, especially oxygen-containing heterocyclic compounds, are crucial moieties in bioactive compounds and drug leads. Substituted chroman-4-ones are a kind of the most significant structural skeletons. Herein, we report a visible-light-induced dual acylation of alkenes for constructing 3-substituted chroman-4-ones, which undergoes a radical tandem cyclization reaction through carbon-carbon bond cleavage of oxime esters by a nitrogen-centered radical strategy. A series of 3-substituted chroman-4-ones were prepared with up to 86% yield.
科研通智能强力驱动
Strongly Powered by AbleSci AI