Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank

哮喘 重性抑郁障碍 医学 精神科 广泛性焦虑症 萧条(经济学) 逻辑回归 调解 虐待儿童 焦虑 临床心理学 毒物控制 心理学 伤害预防 医疗急救 内科学 认知 法学 经济 宏观经济学 政治学
作者
Y.-Y. Han,Qi Yan,Wei Chen,Juan C. Celedón
出处
期刊:The European respiratory journal [European Respiratory Society]
卷期号:60 (4): 2103160-2103160 被引量:9
标识
DOI:10.1183/13993003.03160-2021
摘要

Child maltreatment is associated with asthma in adults. We examined whether lifetime major depressive disorder (MDD) or lifetime generalised anxiety disorder (GAD) mediate an association between child maltreatment and current asthma among 81 105 British adults in the UK Biobank who completed a mental health survey and had complete data on child maltreatment, GAD, MDD, asthma and relevant covariates but no diagnosis of chronic obstructive pulmonary disease.Child maltreatment was ascertained based on answers to the five questions in the Childhood Trauma Screener. Two mediators, lifetime MDD and GAD, were assessed based on the Composite International Diagnostic Interview Short Form. Current asthma was defined as physician-diagnosed asthma and wheeze or whistling in the chest in the previous year. Logistic regression was used for the multivariable analysis of child maltreatment and current asthma, and a mediation analysis was conducted to estimate the contributions of lifetime MDD and lifetime GAD to the child maltreatment-current asthma association.In a multivariable analysis, any child maltreatment was associated with asthma (adjusted OR 1.22, 95% CI 1.15-1.28; p<0.01). In a mediation analysis adjusted for household income, educational attainment, smoking status, pack-years of smoking and other covariates, lifetime GAD and lifetime MDD explained 21.8% and 32.5%, respectively, of the child maltreatment-current asthma association. Similar results were obtained after excluding current smokers and former smokers with ≥10 pack-years of smoking from the mediation analysis.Our findings suggest that GAD and MDD mediate an association between child maltreatment and asthma in adults, independently of smoking.
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