氧化应激
生殖毒性
超氧化物歧化酶
丙二醛
精子
丙烯酰胺
抗氧化剂
DNA损伤
精子活力
男科
内分泌学
毒性
活性氧
谷胱甘肽过氧化物酶
内科学
谷胱甘肽
DNA断裂
过氧化氢酶
脂质过氧化
化学
生物
医学
生物化学
细胞凋亡
酶
程序性细胞死亡
DNA
有机化学
共聚物
聚合物
作者
Hissah Ahmed Alturki,Hany Elsawy,Ademola C. Famurewa
出处
期刊:Andrologia
[Wiley]
日期:2022-06-26
卷期号:54 (9)
被引量:7
摘要
Acrylamide (ACR) is a toxic chemical formed in foods processed at high temperature; it is a food-borne toxicant with increasing public health attention due to its carcinogenic, neurotoxic and reproductive toxicities. However, till date, it is unknown whether silymarin (SIL) could attenuate ACR testicular toxicity. Therefore, the present study investigated the effect of SIL on ACR testiculotoxicity in rats. Rats were randomly divided and administered respective agents in Control group, ACR group, SIL group and ACR + SIL group for consecutive 14 days. Rat exposure to ACR resulted in significant reduction in the level of serum testosterone, whereas FSH and LH levels prominently increased compared to control. Acrylamide induced marked decreases in sperm count and sperm motility followed by a considerable increase in sperm abnormality percentage in the ACR-exposed rats in comparison to control. The testicular activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) were significantly diminished, whereas malondialdehyde (MDA) level considerably increased. Additionally, ACR induced marked DNA fragmentation and histopathological lesions compared to control. Interestingly, the co-treatment of SIL with ACR attenuated the altered reproductive indices and restored antioxidant balance and DNA integrity. Overall, SIL prevents ACR-induced testicular reproductive deficits via modulation of antioxidant mechanism in rats.
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