化学
烯酮
对映选择合成
催化作用
功能群
氢化物
还原(数学)
羧酸
有机化学
组合化学
氢
几何学
数学
聚合物
作者
Yujing Zhou,Jeffrey S. Bandar,Richard Y. Liu,Stephen L. Buchwald
摘要
The copper hydride (CuH)-catalyzed enantioselective reduction of α,β-unsaturated carboxylic acids to saturated aldehydes is reported. This protocol provides a new method to access a variety of β-chiral aldehydes in good yields, with high levels of enantioselectivity and broad functional group tolerance. A reaction pathway involving a ketene intermediate is proposed based on preliminary mechanistic studies and density functional theory calculations.
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