结核分枝杆菌
肺结核
微生物学
药品
药理学
医学
病毒学
生物
病理
作者
Amanda Ronchi Barbosa,Katiany Rizzieri Caleffi-Ferracioli,Clarice Q. F. Leite,Juan Carlos García‐Ramos,Yanis Toledano‐Magaña,Lena Ruíz-Azuara,Vera Ld Siqueira,Fernando Rogério Pavan,Rosilene Fressatti Cardoso
出处
期刊:Chemotherapy
[S. Karger AG]
日期:2016-01-01
卷期号:61 (5): 249-255
被引量:15
摘要
New compounds with antituberculosis activity and their combination with classic drugs have been evaluated to determine possible interactions and antagonism. The aim of this study was to evaluate the in vitro activity of Casiopeínas® copper-based compounds (CasIIIia, CasIIIEa, and CasIIgly) alone and combined with isoniazid (INH), rifampicin, or ethambutol (EMB) against resistant and susceptible Mycobacterium tuberculosis. Seventeen clinical M. tuberculosis isolates (5 multi-drug resistant and 2 resistant to INH and/or EMB) were subjected to determination of the minimal inhibitory concentration (MIC) by the resazurin microtiter assay and combination assessment by the resazurin drug combination microtiter assay. The Casiopeínas® alone showed a remarkable effect against resistant isolates with MIC values from 0.78 to 12.50 μg/ml. Furthermore, a synergistic effect mainly with EMB is shown for both resistant and susceptible clinical isolates. Casiopeínas® are promising candidates for future investigation into the development of antituberculosis drugs, being one of the first examples of essential metal-based drugs used in this field.
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