代谢组学
肠道菌群
肥胖
拟杆菌
脂质代谢
新陈代谢
生物
脂肪组织
食品科学
三羧酸
生物化学
内分泌学
内科学
柠檬酸循环
细菌
生物信息学
医学
遗传学
作者
Lili Li,Yuting Wang,Yi Jin,Zhengyi Liu,Changqing Ye,Song Qin
标识
DOI:10.1007/s00253-020-10954-9
摘要
Dietary fiber has beneficial effects on obesity-related diseases and gut microbiota, contributing a key role in the interaction between dietary metabolism and host metabolism. Our objective was to investigate the cause of the improvement in multiple types of physiological states with seaweed Undaria pinnatifida treatment on high-fat diet-fed mice and to evaluate whether its consequent anti-adiposity and anti-hyperlipidemic effects are associated with gut microbiota and its metabolomics regulation. U. pinnatifida administration in our experiment was shown to significantly decrease high-fat diet-induced body weight gain, as well as epididymal and abdominal adiposity. U. pinnatifida intake also significantly reduced liver weight and serum triacylglycerol accumulation. We also found that improving effects of U. pinnatifida on high-fat diet-induced metabolic dysfunctions were associated with significant increase in specific bacteria, such as Bacteroides acidifaciens and Bacteroides ovatus, as well as metabolites, including short-chain fatty acids and tricarboxylic acid cycle intermediates. Our result provides a cheap dietary strategy to host metabolism improvement and obesity management. KEY POINTS: • U. pinnatifida improved adipose accumulation and lipid metabolism. • B. acidifaciens and B. ovatus contributed to the beneficial effects of U. pinnatifida. • SCFAs and TCA cycle intermediates were critical to the metabolic outcomes. • Our study provides a cheap dietary strategy for obesity management.
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