免疫系统
炎症
生物
胰岛素抵抗
免疫学
肥胖
疾病
2型糖尿病
血糖性
发病机制
串扰
糖尿病
获得性免疫系统
先天免疫系统
免疫
内科学
内分泌学
医学
物理
光学
作者
Mukul Prasad,Elijah W. Chen,Sue‐Anne Toh,Nicholas R. J. Gascoigne
标识
DOI:10.1002/jlb.3mr0220-243r
摘要
Abstract Obesity-induced insulin resistance is one of the largest noncommunicable disease epidemics that we are facing at the moment. Changes in lifestyle and greater availability of low nutritional value, high caloric food has led to the highest rates of obesity in history. Obesity impacts the immune system and obesity-associated inflammation contributes to metabolic diseases, such as type 2 diabetes. Both the adaptive and the innate immune system play a role in the regulation of glycemic control, and there is a need to understand how metabolic imbalances drive disease pathogenesis. This review discusses the cell types, mediators, and pathways that contribute to immunologic–metabolic crosstalk and explores how the immune system might be targeted as a strategy to treat metabolic disease.
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