共济失调
高强度
背景(考古学)
医学
认知功能衰退
磁共振成像
萧条(经济学)
脑脊液
病理
儿科
冲程(发动机)
基底神经节
痴呆
疾病
放射科
内科学
精神科
中枢神经系统
经济
古生物学
宏观经济学
工程类
生物
机械工程
作者
Dina N Osman,Alice Weidner,Mayuri Madhra
标识
DOI:10.4997/jrcpe.2020.313
摘要
We report the case of a 67-year-old male who presented with a six-week history of progressive unsteadiness, cognitive impairment and weight loss, in the context of a recent bereavement. Magnetic resonance imaging (MRI) performed several weeks earlier excluded acute stroke. Examination revealed gross bilateral ataxia, bradyphrenia and physical manifestations of depression. Collateral history suggested rapidly progressing symptoms over three months. Repeat MRI head showed features suggestive of Creutzfeldt-Jakob disease (CJD) including T2 hyperintensities in the basal ganglia. Cerebrospinal fluid (CSF) samples were positive for 14-3-3 protein, S100b and real-time quaking-induced conversion (RT-QuIC) proteins confirming the diagnosis of sporadic CJD (sCJD).
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