焦点粘着
整合素
PTK2
细胞外基质
细胞生物学
肌动蛋白细胞骨架
细胞粘附
信号转导
粘附
细胞骨架
帕西林
细胞迁移
肌动蛋白
化学
生物
细胞
蛋白激酶C
生物化学
丝裂原活化蛋白激酶激酶
有机化学
作者
Michele A. Wozniak,Katarzyna Modzelewska,Lina Kwong,Patricia J. Keely
标识
DOI:10.1016/j.bbamcr.2004.04.007
摘要
Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin cytoskeleton. Cells modify focal adhesions in response to changes in the molecular composition, two-dimensional (2D) vs. three-dimensional (3D) structure, and physical forces present in their extracellular matrix environment. We consider here how cells use focal adhesions to regulate signaling complexes and integrin function. Furthermore, we examine how this regulation controls complex cellular behaviors in response to matrices of diverse physical and biochemical properties. One event regulated by the physical structure of the ECM is phosphorylation of focal adhesion kinase (FAK) at Y397, which couples FAK to several signaling pathways that regulate cell proliferation, survival, migration, and invasion.
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